Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells. Mar 10, 2016 · Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells Skip to main content Thank you for visiting. Dual aptamer modified dendrigraft poly-l-lysine nanoparticles for overcoming multi-drug resistance through mitochondrial targeting† Huachao Chen, ‡ ab Jiangwei Tian, ‡ b Danyang Liu, a Weijiang He a and Zijian Guo a. Overcoming drug resistance is one of the most challenging problems in cancer chemotherapy. Drug cocktails can overcome the drug resistance. However, multiple drug combinations lead to multifold increment of off-target toxicity, as well as the delivery of the required therapeutic amount of combined drugs remains problematic. well-established orally available AKT inhibitor, A674563, as a dual suppressor of AKT and FLT3-ITD. A674563 suppressed FLT3-ITD positive AML both in vitro and in vivo. More importantly, compared to other FLT3 inhibitors, A674563 is able to overcome FLT3 ligand-induced drug resistance through simultaneous inhibition of FLT3-ITD
Sep 10, 2018 · Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS. histone H3K27 acetylation of the IGF1 promoter tracked closely with drug resistance of MSR-A549 cells and was highly reversible. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc. Natl. Acad. Chemotherapy research highly prioritizes overcoming the multi-drug resistance MDR effect in cancer cells. Oct 11, 2018 · In many instances, drug resistance is correlated with aberrant metabolic adaptations that favor aerobic glycolysis over oxidative phosphorylation. To date, efforts have been made to overcome resistance by targeting the metabolic changes associated with resistance, albeit with limited effect. In this study, we proposed a tumor-associated macrophage TAM reprogramming strategy for overcoming the EGFRT790M-associated drug resistance via a dual-targeting codelivery system of gefitinib/vorinostat that acted on both TAM with overexpression of mannose receptors and the HER-2 positive NSCLC cells.
Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury Author Jennifer Dulin, The University of Texas Graduate School of Biomedical Sciences at Houston Follow. Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug Sharmaetal.reportacancer-selectivemulticomponentstrategytoovercomedrug resistancel. The current strategy centers around a conjugate that triggers a reprogramming of the mitochondrial metabolism. This results in delayed prodrug. Mitochondria play a critical role in diverse cellular processes, such as energy production and apoptosis regulation. The mitochondria-targeted drug delivery is becoming a potential novel strategy for overcoming drug resistance in cancer therapy. Herein, we synthesize nature-inspired dopamine-derived polydopamine PDA nanoparticles.
Jun 26, 2015 · Part 2: Overcoming resistance to anti-EGFR antibody therapies In an earlier post, we looked at the challenges and potential treatment strategies for lung cancer patients whose epidermal growth factor receptor EGFR-mutant tumors develop drug resistance following treatment with EGFR tyrosine kinase inhibitors TKIs. Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Giulia Bon 1, Rossella Loria,. be trans-phosphorylated through hetero-dimerization with other family members, such as HER2 [16–18]. Heterodimers. with the aim to overcome the mechanism of drug resistance.
 NT-219, A FIRST-IN- CLASS DUAL INHIBITOR OF STAT3 AND IRS1/2 IS OVERCOMING DRUG RESISTANCE Hadas Reuveni, CEO, Tyrnovo LTD, Tel Aviv, Israel Investment Rational TyrNovo Ltd. a Kitov Pharma subsidiary is a pharmaceutical company that develops NT219 - an innovative first-in-class small molecule to overcomes cancer drug resistance. Nanomedicines are being investigated for their use in anticancer therapies to improve drug delivery, increase the efficacy of treatment, reduce side effects, and overcome drug resistance. The number of studies published under the research topics of “nanomedicine,” “nanoscience,” and “nanotechnology” has increased exponentially over the past decade with a slight decline in 2012, as shown in Fig. 1. Feb 08, 2018 · Production of ROS in mitochondria to combat drug resistance.Overcoming drug resistance by targeted production of reactive oxygen species in mitochondria. a When irradiated with NIR laser, the LSC nanoparticles can specifically produce reactive oxygen species ROS in mitochondria. This oxidizes NADH into NADto inhibit the production of ATP.
"We talk about personalizing cancer treatment, but I think personalizing treatment to overcome drug resistance is also an important concept," echoed Dr. Gottesman. But the enormous number of drug combinations that would need to be tested to find the best match for each patient is a daunting impediment to this precision approach. Apr 02, 2019 · The combination of chemotherapy and photodynamic therapy opens up a promising way of overcoming drug resistance, incorporating different mechanisms of actions to achieve synergistic efficacy. However, the antitumor outcome of photodynamic therapy is greatly limited due to the unsatisfactory singlet oxygen generation caused by severe aggregation of the photosensitizer. Dual Drug Targeting of Mutant Bcr‐Abl Induces Inactive Conformation: New Strategy for the Treatment of Chronic Myeloid Leukemia and Overcoming Monotherapy Resistance Ahmed A. El Rashedy Molecular Modeling and Drug Design Research Group, School of Health Sciences, University of KwaZulu‐Natal, Westville Campus, Durban, 4001 South Africa.
Through further metabolic changes, the resistance develops to the anaerobic resistance stage, which was demonstrated in vitro by prolonged treatment and drug pressure. This stage is oxygen-independent and characterized by advanced gradual loss of PFOR, the key enzyme in the drug activation pathway. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer Lucia Regales, 1 Yixuan Gong, 1 Ronglai Shen, 2 Elisa de Stanchina, 3 Igor Vivanco, 4 Aviva Goel, 1 Jason A. Koutcher, 5 Maria Spassova, 6 Ouathek Ouerfelli, 6 Ingo K. Mellinghoff, 4 Maureen F. Zakowski, 7 Katerina A. Politi, 8 and. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. as dual targeting with cetuximab and a second-generation EGFR TKI may be an effective strategy to overcome T790M-mediated drug resistance. Usage data is cumulative from September 2018 through September 2019. Usage JCI PMC. Resistance R factors: plasmids containing antibiotic resistance genes Can be transferred through conjugation, transformation, or transduction Plasmids encoded with drug resistance are naturally present in microbes before they have been exposed to an antibiotic Transposons also duplicate and insert genes for drug resistance into plasmids.
including dual-targeting therapy dual and tandem CAR, and armored and universal CAR T-cell therapies. In this review, we provide an overview of resistance mechanisms to CD19 CAR T-cell therapy in B-cell malignancies and also review therapeutic strategies to overcome these resistances.
Apr 02, 2015 · Dual Therapy’s One-Two Punch Knocks Out Drug-Resistant Lung Cancer. Combined drug regimens designed to overcome drug resistance at the outset of therapy are now the norm in treating certain forms of melanoma, said Bivona, and he believes PBS-1086 “has a shot” to play a similar role in NSCLC. UCSF is dedicated to transforming. It was not known whether mechanisms of resistance to dual-agent chemotherapy are a combination of single-agent resistance responses or if novel mechanisms arise as a result of combined platinating. VEGF-inhibitor effects and go through ‘angiogenic escape’. Potential mechanisms are discussed below. Gene mutation: a critical component of the pathway Although this is a common mechanism of drug resistance in some cancers [39–42], mutation is thought to be an unlikely explanation for resistance to.
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